Sunday, September 1, 2013
My new revelation
It just dawned on my at 4am this morning when I woke up in the middle of the night. The cluster of low ANC and needing blood and platelets transfusion throughout Lucas's treatment has been (1) in induction (2) in consolidation (3) in second half of DI. I earlier concluded that AraC hits Lucas really hard and always result in low blood counts for him. Now I looked in more details, I found the three times we used AraC, Lucas also got either 60mg 6mp or 75mg 6TG(very similar to 6mp). So my new hypothesis is that Lucas is very sensitive to 6mp/6TG.
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Have they tested him for it? They can. They tested Nico for 6MP sensitivity after he crashed during IM. Of course, they're only looking at one particular enzyme in the metabolism, and my guess is that there are more steps than what they are testing. I have a hypothesis that Nico is sensitive to Septra, but I won't find out anytime soon because our clinic is very resistant to switching.
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